Amiodarone and thyroid dysfunction - UpToDate Jan 2 20Amiodarone, a class III antiarrhythmic drug, has multiple effects on myocardial depolarization and repolarization that make it an extremely effective antiarrhythmic drug. Heart Feb 0 19Although most patients remain clinically euthyroi a significant minority (up to of patients in the UK and the USA) develop amiodarone induced hypothyroidism or thyrotoxicosis.9-Unfortunately, amiodarone induced thyroid dysfunction is rarely manageable by discontinuation of amiodarone alone, partly because it has an extremely long terminal half life (up to four months).13. For those living in iodine-depleted areas, the incidence is higher (10). It is a benzofuran-derive iodine-rich compound with some structural similarity to thyroxine (T4).
Oct 0 20Amiodarone is a potent antiarrhythmic drug that is used to treat ventricular and supraventricular tachyarrhythmias.
The Mechanism for Amiodarone-Induced Hyperthyroidism and
However, amiodarone is associated with a number of side effects, including thyroid dysfunction (both hypo- and hyperthyroidism which is due to amiodaroneaposs high iodine). Amiodarone-induced thyrotoxicosis: A review Nov 2 20Amiodarone-induced thyrotoxicosis (AIT) develops in of amiodarone-treated patients in North America. This is a condition called type I amiodarone induced thyrotoxicosis (hyperthyroidism).5-Type I amiodarone induced thyrotoxicosis (AIT) is more likely to occur in patients who live in areas of low iodine intake or have some form of underlying thyroid disease (such as multinodular goiter, latent Graveaposs disease, etc.) where the iodine exposure could possibly trigger thyroid hormone production.8.
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Thyroid Dysfunction Induced by Amiodarone Therapy
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